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Stabilization of labile active ingredients in an oil-water emulsion cosmetics by freeze-drying
1Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Background:
Due to the instability in oil/water emulsion, certain labile active ingredients were often not used in cosmetics.
Objective:
The present study has tested the effect of freeze-drying to stabilize an oil/water cosmetic emulsion.
Materials And Methods:
A preliminary freeze-drying process was established at the basis of calorimetric and freeze-drying microscope studies. The stability of labile molecules in the cosmetic emulsion was evaluated at 48 degree C after freeze-drying.
Results:
The accelerated stability experiment showed that the freeze-dried emulsion retained 90.1% vitamin C after 28 days at 48 degree C, whereas the oil-water emulsion retained only 28.3% vitamin C. The freeze-dried emulsion had significantly less oil oxidation than did the oil-water emulsion.
Conclusion:
Freeze-drying improved the stability of vitamin C and oily active ingredients in cosmetic emulsions. DOI: 10.54680/fr23210110312.
