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Related Concept Videos

Brain Imaging01:14

Brain Imaging

235
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
235

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Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
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Dose-response in modulating brain function with transcranial direct current stimulation: From local to network

Ghazaleh Soleimani1, Rayus Kupliki2, Martin Paulus2

  • 1Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America.

Plos Computational Biology
|October 26, 2023
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Summary

This study explored how transcranial direct current stimulation (tDCS) dose relates to brain responses in individuals with methamphetamine use disorder. Network-level brain connectivity showed a significant correlation with the simulated electric field dose.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Brain Stimulation

Background:

  • Understanding dose-response relationships is vital for brain stimulation techniques like transcranial direct current stimulation (tDCS).
  • Previous research has focused on various levels of analysis, from neuronal to network scales.
  • Computational modeling and functional magnetic resonance imaging (fMRI) are key tools for quantifying stimulation dose and brain response.

Purpose of the Study:

  • To investigate the dose-response relationship between simulated electric fields and brain activity changes in individuals with methamphetamine use disorder (MUDs) receiving tDCS.
  • To evaluate this relationship across multiple analytical levels: voxel, region, cluster, and network.
  • To establish a methodological framework for linking electric field variability to neural responses in tDCS studies.

Main Methods:

  • A randomized, triple-blind, sham-controlled trial involving 60 participants with MUDs undergoing tDCS.
  • Acquisition of structural and functional MRI data before and after tDCS.
  • Generation of individual head models to simulate electric fields and linear analysis of associations between electric fields and fMRI-derived brain activity changes at voxel, regional, cluster, and network levels.

Main Results:

  • No significant FDR-corrected correlations were found between electric fields and functional activity changes at the voxel, regional, or cluster levels.
  • A significant positive correlation (r = 0.42, p = 0.02) was observed at the network level between frontoparietal connectivity and the electric field at the frontopolar stimulation site.
  • This indicates a medium effect size for the network-level association.

Conclusions:

  • Network-level analysis is crucial for understanding the dependency of tDCS neuromodulatory effects on individual current dose.
  • The proposed pipeline provides a framework for analyzing tDCS dose-response relationships.
  • Integrating dose-response findings can guide dose optimization and biomarker discovery in future brain stimulation research.