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Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
Aigul Kh Valiullina1, Ekaterina A Zmievskaya1, Irina A Ganeeva1
1Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Abstract:
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2.26 million new cases of cancer in 2020. Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of solid tumors, such as breast cancer. In this work the effectiveness of CAR-T cells against monolayer and three-dimensional bioprinted tumor-like structures made of modified MCF-7 breast cancer cells was assessed. The cytokine profile of supernatants after co-cultivation of MCF-7 tumor cell models with CAR-T cells was also measured to reveal the inflammatory background associated with this interaction.
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