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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

Linking Clinical Blood Metabogram and Gut Microbiota.

Petr G Lokhov¹, Elena E Balashova¹, Dmitry L Maslov¹

¹Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.

|October 27, 2023

Summary

A new clinical blood metabogram links metabolite profiles to gut bacteria. This research validates the metabogram for diagnosing gut microbiota changes in clinical practice.

Keywords:

blood clinical blood test clinical metabolomics diagnostics gut microbiome gut microbiota mass spectrometry metabogram metabolomics personalized metabolomics

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An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

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Published on: October 20, 2018

Area of Science:

Clinical metabolomics
Gut microbiome research
Biomarker discovery

Background:

A clinical blood metabogram offers a rapid, cost-effective method for integrating metabolomics into healthcare.
The gut microbiota influences blood metabolites, and vice-versa, necessitating an understanding of this relationship before clinical application of the metabogram.

Purpose of the Study:

To establish the link between clinical blood metabogram components and gut microbial composition.
To assess the diagnostic potential of metabogram components for identifying gut microbiota alterations.

Main Methods:

Blood plasma metabograms were analyzed using direct mass spectrometry.
Gut microbiome composition was determined via culture-based methods and real-time PCR.
Correlation analysis was performed on data from 44 healthy and overweight individuals.

Main Results:

Specific metabogram components were found to be significantly correlated with particular gut microorganisms.
Diagnostic parameters demonstrated the metabogram's capability to detect gut microbiota dysbiosis.
The study identified key links between blood metabolites and gut microbial populations.

Conclusions:

The clinical blood metabogram can be reliably used in healthcare settings.
The established correlations support the metabogram's utility in diagnosing gut microbiota status.
This research bridges metabolomics and microbiome science for clinical applications.