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Related Experiment Video

Updated: Jul 12, 2025

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies.

Aleria Aitova^1,2,3, Andrey Berezhnoy^1,2,3, Valeriya Tsvelaya^1,2,3

¹Laboratory of Experimental and Cellular Medicine, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia.

Biomimetics (Basel, Switzerland)

|October 27, 2023

Summary

This summary is machine-generated.

Tissue engineering models offer new ways to study cardiac arrhythmias caused by reentry. These biomimetic cardiac tissues, combined with computational modeling, enhance understanding of wave propagation and arrhythmia mechanisms.

Keywords:

arrhythmias cardiac model cardiac tissue cardiomyocytes excitation wave ion currents ips cells reentry

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Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

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Last Updated: Jul 12, 2025

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

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Published on: June 16, 2020

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

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Published on: June 2, 2023

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Area of Science:

Biomedical Engineering
Cardiovascular Research
Tissue Engineering

Background:

Cardiac arrhythmias, a leading cause of death, are often driven by reentry phenomena.
Investigating reentry mechanisms in intact hearts is challenging.
Optical mapping has provided insights but lacks mechanistic detail.

Purpose of the Study:

To review tissue engineering approaches for studying cardiac reentry.
To highlight advancements in biomimetic cardiac tissue models.
To demonstrate the synergy between experimental and computational cardiac modeling.

Main Methods:

Review of diverse tissue engineering strategies for cardiac models.
Examples of substrate, cell type, and structural parameter variations.
Introduction of novel polymer-based biomimetic tissues using cellular reprogramming.

Main Results:

Tissue engineering models successfully mimic native cardiac tissue structure and function.
These models allow direct observation of reentry formation and wave propagation.
Computational modeling complements experimental findings for deeper mechanistic insights.

Conclusions:

Engineered cardiac tissues provide powerful platforms for studying arrhythmias.
Advancements in biomaterials and cellular reprogramming yield more accurate models.
Integrated experimental and computational approaches are crucial for understanding cardiac electrophysiology.