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A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

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A Predictive and an Optimization Mathematical Model for Device Design in Cardiac Pulsed Field Ablation Using Design

Eoghan Dunne¹, Jara M Baena-Montes², Kevin Donaghey³

¹Translational Medical Device Lab (TMD Lab), Lambe Institute for Translational Research, School of Medicine, University of Galway, H91 TK33 Galway, Ireland.

Journal of Cardiovascular Development and Disease

|October 27, 2023

Summary

This summary is machine-generated.

Design of Experiments (DoE) optimizes Pulsed Field Ablation (PFA) device design for cardiac arrhythmia correction. This method accurately predicts ablation size, aiding PFA device development and arrhythmia treatment.

Keywords:

atrial fibrillation cardiomyocytes design of experiments in vitro pulsed field ablation

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Area of Science:

Biomedical Engineering
Medical Devices
Cardiac Electrophysiology

Background:

Cardiac catheter ablation (CCA) is a standard treatment for cardiac arrhythmias.
Pulsed Field Ablation (PFA) is an emerging CCA technology.
PFA's effectiveness depends on electrode and waveform parameters.

Purpose of the Study:

Investigate the Design of Experiments (DoE) methodology for PFA device design and optimization.
Analyze the impact of key factors and their interactions on PFA ablation size.
Develop an empirical model for predicting and optimizing ablation zone dimensions.

Main Methods:

Applied Design of Experiments (DoE) methodology.
Evaluated four factors: input voltage, electrode spacing, electrode width, and on-time.
Developed an empirical model to predict ablation size.

Main Results:

Input voltage, electrode spacing, and on-time were identified as significant factors.
Two-factor interactions were found to be significant and incorporated into the model.
The empirical model predicted ablation sizes with less than 2.1% error.

Conclusions:

DoE is a valuable approach for PFA device design and optimization.
The predictive model can guide PFA device development for specific ablation zone sizes.
Findings support informed device design for treating cardiac arrhythmias effectively.