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Updated: Jul 12, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Diastereoselective Ring Expansion of Cyclic Ketones Enabled by HAT-Initiated Radical Cascade
Wenxue Wang1, Shouyang Feng1, Yansheng Wei1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Abstract:
Herein we disclose an iron-catalyzed method for stereoselective synthesis of multisubstituted cyclic ketones containing a synthetically challenging quaternary carbon from readily accessible β-vinyl keto esters in good yields. This cascade reaction is initiated by a hydrogen atom transfer (HAT) process, after which a Dowd-Beckwith-type ring-expansion reaction occurs. This strategic transformation offers access to synthetically valuable cyclic ketones bearing two contiguous stereocenters, including quaternary stereocenters, which hold paramount significance within the realm of synthetic chemistry.
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