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Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy
Ryuzaburo Kochi1, Shin-Ichiro Osawa1, Kazutaka Jin2
1Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Preoperative language lateralization measured by magnetoencephalography (MEG) may predict improved verbal memory (VM) after surgery in patients with left mesial temporal lobe epilepsy (LMTLE) and hippocampal sclerosis (HS+). Further research is needed.
Area of Science:
- Neuroscience
- Epilepsy Research
- Cognitive Neuroscience
Background:
- Left mesial temporal lobe epilepsy (LMTLE) often affects verbal memory (VM) due to proximity to language areas.
- Predicting postsurgical VM changes is crucial for surgical planning in LMTLE patients.
Conclusions:
- Rightward language lateralization, as assessed by dSPM in MEG signals, may predict favorable VM outcomes in LMTLE patients with hippocampal sclerosis.
- These findings suggest that regional language lateralization is a potential biomarker for predicting postsurgical cognitive changes in LMTLE.
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