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Related Experiment Video

Updated: Jul 12, 2025

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Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.

Syed Mujtaba1,2, Ishan Kumar Patro1,2, Nisha Patro1

  • 1School of Studies in Neuroscience, Jiwaji University, Gwalior 474011, India.

Brain Sciences
|October 28, 2023
PubMed
Summary

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Microglial Dystrophy and Spatial Learning Impairments Following Exposure to Multiple Early-life Stressors in Rats.

Annals of neurosciences·2025
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Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology.

Biology open·2022
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Early life exposure to poly I:C impairs striatal DA-D2 receptor binding, myelination and associated behavioural abilities in rats.

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Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors.

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Poly (I:C) Exposure in Early Life Alters Methylation of DNA and Acetylation of Histone at Synaptic Plasticity Gene Promoter in Developing Rat Brain Leading to Memory Impairment.

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A Sequential Study of Age-Related Lipofuscin Accumulation in Hippocampus and Striate Cortex of Rats.

Annals of neurosciences·2019

Early life exposure to low protein diets and environmental toxins like deltamethrin (DLT) and lipopolysaccharide (LPS) significantly increases susceptibility to behavioral abnormalities. These findings suggest a predisposition to neurodevelopmental disorders such as schizophrenia and ADHD.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Early life stress is linked to increased risk of neuropsychiatric disorders.
  • Animal models are crucial for understanding the long-term effects of early life exposures on behavior.

Purpose of the Study:

  • To investigate the impact of cumulative early life stressors, including a low protein (LP) diet and exposure to deltamethrin (DLT) and lipopolysaccharide (LPS), on behavioral development in a rat model.
  • To assess neurobehavioral impairments during adolescence and adulthood.

Main Methods:

  • Female Wistar rats were fed either a control (20% protein) or LP (8% protein) diet pre-conception and throughout gestation/lactation.
  • Pups were exposed to DLT (insecticide), LPS (bacterial endotoxin), or both, during the postnatal period (PND 1-7).
Keywords:
ADHDhyperactivitylow anxietymulti-hit stressprotein malnourishmentschizophrenia

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  • Neurobehavioral assessments (open field, elevated plus maze, light/dark box, rotarod) were conducted at 1, 3, and 6 months of age.

    • Main Results:

    • Rats exposed to LP diets showed heightened susceptibility to singular or combined DLT and LPS exposures.
    • Significant behavioral abnormalities, including hyperactivity, attention deficits, and reduced anxiety, were observed in LP-exposed rats.
    • These behavioral changes mimic symptoms associated with neuropsychiatric disorders like schizophrenia and ADHD.

    Conclusions:

    • Cumulative early life exposure to nutritional deficits and environmental toxins can lead to significant and lasting behavioral impairments.
    • This multi-hit model suggests a potential mechanism predisposing individuals to developmental disorders.
    • Early life interventions may be critical for mitigating the long-term consequences of such exposures.