Related Experiment Video
Updated: Jul 12, 2025

09:02
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
19.5K
Breast and Formula Milk and Early Puberty Onset
Valeria Calcaterra1,2, Hellas Cena3,4, Francesca Sottotetti3
1Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Children (Basel, Switzerland)
|October 28, 2023
Summary
Infant nutrition significantly influences puberty timing. Breast milk may protect against early puberty, while soy formula effects remain unclear, necessitating further research for optimal child development.
Area of Science:
- Pediatric Endocrinology
- Nutritional Science
- Microbiome Research
Background:
- Nutrition status critically regulates growth and pubertal development in children and adolescents.
- Hormonal systems and overall health are significantly impacted by nutrient intake.
- The timing of puberty is a key biological milestone in human development.
Purpose of the Study:
- To review the relationship between infant feeding methods and the onset of puberty.
- To clarify how early nutrition influences pubertal timing.
- To explore the role of breast milk, formula, and soy-based formulas in puberty development.
Main Methods:
- Narrative review of existing scientific literature.
- Analysis of studies on infant nutrition and pubertal development.
- Examination of the impact of breast milk, formula, and soy isoflavones.
Main Results:
- Breast milk appears to have a protective role in puberty onset, potentially via gut microbiota modulation.
- Soy-based formulas and their isoflavones show conflicting results regarding pubertal timing, requiring more research.
- Early life nutrition is vital for long-term health and disease prevention.
Conclusions:
- Infant feeding practices, particularly breastfeeding, play a crucial role in regulating the timing of puberty.
- Further investigation is needed to understand the effects of soy-based formulas on pubertal development.
- Establishing a healthy diet early in life is essential for preventing future health issues.
Related Concept Videos
Signs of Puberty
375
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
375
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Hormonal Regulation of the Menstrual Cycle
408
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
408
The Mammary Glands
639
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
639
Nature and Nurture
20.5K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Hormonal Regulation
33.2K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.2K

