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Correlation between Serum 25-Hydroxyvitamin D Concentration, Monocyte-to-HDL Ratio and Acute Coronary Syndrome in Men
Ewelina A Dziedzic1, Jakub S Gąsior2, Agnieszka Tuzimek1
1Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
Insights
The monocyte-to-HDL ratio (MHR) and vitamin D levels differ between chronic coronary syndrome (CCS) and acute coronary syndrome (ACS) patients. Higher vitamin D and HDL were seen in CCS, while ACS patients had higher MHR, suggesting a link requiring further study.
Area of Science:
- Cardiology
- Biochemistry
- Nutritional Science
Background:
- Cardiovascular disease (CVD) is a leading cause of death in European men, with atherosclerosis and chronic coronary syndrome (CCS) being major contributors.
- CCS involves lipoprotein metabolism dysfunction and inflammation, increasing risks for complications like acute coronary syndrome (ACS).
- The monocyte-to-HDL ratio (MHR) is a composite marker reflecting both inflammation and lipoprotein metabolism, while vitamin D deficiency is linked to CVD risk factors.
Purpose of the Study:
- To investigate differences in MHR and 25-hydroxyvitamin D (25(OH)D) concentrations among male patients with varying CCS diagnoses.
- To explore the correlation between 25(OH)D and MHR in male patients with CCS.
Main Methods:
- Comparison of MHR and total serum 25(OH)D levels between male patients diagnosed with different forms of CCS and ACS.
- Correlation analysis between 25(OH)D, HDL, and MHR.
Main Results:
- Significant differences in 25(OH)D and MHR were observed between ACS and CCS patient groups.
- Patients with CCS exhibited higher HDL and serum 25(OH)D concentrations compared to ACS patients.
- STEMI patients (a type of ACS) presented with the highest MHR values.
Conclusions:
- A significant correlation exists between 25(OH)D, HDL, and MHR in the studied male population.
- While nominal differences in MHR between ACS and CCS exist, further research is needed due to potential confounding factors like age and hyperlipidemia.
- The potential bidirectional relationship between MHR and 25(OH)D, and MHR's utility as a vitamin D status predictor, warrant further investigation.
Abstract:
Cardiovascular disease (CVD) continues to be the leading cause of death in European men. Atherosclerosis and its clinical consequence, chronic coronary syndrome (CCS), comprise two main elements: dysfunction of lipoprotein metabolism and an important inflammatory component that contributes to the development of complications, including acute coronary syndrome (ACS). Measures of both components are combined in a composite marker called monocyte-to-HDL ratio (MHR). Vitamin D was previously described to influence inflammation processes, and its deficiency influences CVD risk factors. This research describes the differences in MHR and total serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of CCS and the correlation between 25(OH)D and MHR in this group. Significant differences were observed between ACS and CCS patients in 25(OH)D and MHR-the highest HDL and serum 25(OH)D concentrations were observed in patients with CCS, whereas the highest value of MHR was observed in patients with STEMI. A significant correlation was observed between 25(OH)D, HDL, and MHR. Due to the significant but small nominal difference in MHR values between groups of patients diagnosed with ACS and CCS, and the possible influence of age and hyperlipidemia status on the differences in vitamin D levels in these groups, this subject requires further well-designed research. The suggested bidirectional relationship between MHR and 25(OH)D and the role of MHR as a predictor of vitamin D status in the body also needs to be verified.
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