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Effect of Probiotic Therapy on Neuropsychiatric Manifestations in Children with Multiple Neurotransmitter Disorders:

Loredana Matiș1, Bogdana Ariana Alexandru1, Radu Fodor1

  • 1Faculty of Medicine and Pharmacy, Medicine Department, University of Oradea, 410068 Oradea, Romania.

Biomedicines
|October 28, 2023
PubMed

Insights

Psychobiotics, beneficial gut bacteria, show promise in improving children's behavior and concentration. This study found they can reduce hyperactivity and aggression in children with gastrointestinal and psychoemotional disorders.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Psychiatry

Background:

  • Probiotics, or psychobiotics, are linked to cognitive functions, memory, learning, and behavior.
  • Their positive effects extend beyond the digestive tract to influence mental well-being.

Purpose of the Study:

  • To examine the psychoemotional effects and cognitive functioning in children with gastrointestinal disorders undergoing psychobiotherapy.
  • To assess the impact of psychobiotics on neurotransmitter levels and neuropsychiatric symptoms.

Main Methods:

  • 135 children aged 5-18 with gastrointestinal issues were divided into control, psychoanxiety, and psychiatric disorder groups.
  • Neurotransmitter levels (serotonin, GABA, glutamate, cortisol, DHEA) were monitored.
  • Neuropsychiatric symptoms (headaches, fatigue, mood swings, hyperactivity, aggressiveness, sleep disorders, concentration) were assessed.

Main Results:

  • Psychobiotics significantly reduced hyperactivity and aggression in children.
  • Improvements were observed in concentration levels.
  • The study provides insights into the gut-brain axis in pediatric neuropsychiatric conditions.

Conclusions:

  • Psychobiotics demonstrate a significant impact on reducing problematic behaviors like hyperactivity and aggression.
  • These findings suggest psychobiotics as a potential therapeutic avenue for balancing neuropsychic behavior in children.
  • Further extensive research is warranted to fully understand the complex interplay between gut health and child psychology.

Keywords:
gastrointestinal disordersneuropsychological imbalanceneurotransmitterpsychobiotics

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