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Pattern of Residual Submucosal Involvement after Neoadjuvant Therapy for Rectal Cancer: A Rationale for the Utility
Haidy Elazzamy1, Monika Bhatt1, Paul Mazzara1
1Pathology Department, Ascension St. John Hospital, Detroit, MI 48236, USA.
Medicina (Kaunas, Lithuania)
|October 28, 2023
Summary
Local excision for rectal cancer after neoadjuvant therapy may miss residual cancer. Submucosal involvement is common, suggesting endoscopic submucosal resection could replace full-thickness excision for organ preservation and accurate staging.
Area of Science:
- Colorectal Surgery
- Oncology
- Pathology
Background:
- Organ preservation is key in locally advanced rectal cancer (LARC) treatment.
- Transanal local excision is used post-neoadjuvant therapy but has complications.
- Submucosal involvement post-neoadjuvant therapy needs further investigation.
Conclusions:
- High submucosal involvement in residual LARC tumors after neoadjuvant therapy is confirmed.
- ESR may serve as a restaging tool for organ preservation strategies.
- Further studies are needed due to the retrospective design and sample size.
