Nucleoside Analogs: A Review of Its Source and Separation Processes

Area of Science:

• Biomedical research
• Chemical synthesis
• Drug development

Background:

• Nucleoside analogs are vital for producing antitumor and antimicrobial drugs.
• Current production methods (degradation, synthesis, biotransformation) suffer from low yields, complex matrices, and by-products.
• These limitations hinder the development and study of new nucleoside analog drugs.

Purpose of the Study:

• To review universal separation methods for nucleoside analogs.
• To explore the application of molecular imprinting techniques (MITs) in nucleoside analog separation.
• To compare molecularly imprinted polymer (MIP) adsorbents for nucleoside analog purification.

Main Methods:

• Crystallization
• High-performance liquid chromatography (HPLC)
• Column chromatography
• Solvent extraction
• Adsorption
• Molecular imprinting techniques (MITs)

Main Results:

• Existing separation methods present challenges in yield and purity.
• Molecularly imprinted polymers (MIPs) show promise for selective separation of nucleoside analogs.
• Improved separation techniques are essential for efficient nucleoside production.

Conclusions:

• Developing novel, selective separation and purification methods for nucleosides is critical.
• Enhanced purification of nucleoside analogs supports the development of essential antitumor and antiviral drugs.
• Advances in nucleoside separation offer significant benefits for environmental, biomedical, and clinical applications.