Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.2K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.2K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

296
The pathophysiology of pneumonia involves the following steps:
296

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A machine learning approach to identify active polysorbate 20 degrading hydrolases in biopharmaceutical formulations.

Journal of pharmaceutical sciences·2026
Same author

Drug-Metabolizing Enzymes in Human Keratinocytes and In Vitro Detection of Cytochrome P450-Mediated Phenolic Lamotrigine Metabolite.

Chemical research in toxicology·2026
Same author

Phosphatidylcholine-Polysorbate 20-Based Mixed Micelles: A New Option to Prevent Protein Aggregation?

Pharmaceutics·2026
Same author

Leishmanicidal Action of the Peptides 19-4LF, 19-2.5 and 19-2.5LF Topically Administered on Cutaneous Lesions Caused by <i>Leishmania major</i>.

Pharmaceutics·2026
Same author

CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.

Nature communications·2026
Same author

Do we worry too much about polysorbate degradation? An industry-wide perspective with real-life case studies.

Journal of pharmaceutical sciences·2026

Related Experiment Video

Updated: Jul 12, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.4K

A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis.

Klaus Brandenburg1, Raquel Ferrer-Espada2,3, Guillermo Martinez-de-Tejada2

  • 1Brandenburg Antiinfektiva, c/o Forschungszentrum Borstel, Leibniz-Lungenzentrum, Parkallee 10, 23845 Borstel, Germany.

International Journal of Molecular Sciences
|October 28, 2023
PubMed
Summary

Sepsis and COVID-19 share similarities in their inflammatory responses, involving lipopolysaccharides (LPS) and Toll-like receptor 4 (TLR4) signaling. This review analyzes their pathophysiological, epidemiological, and molecular connections.

Keywords:
ARDSAspidaseptCOVID-19 pandemicGram-negative bacteriaTLR4cytokineshyperinflammationlipopolysaccharidesepsis

More Related Videos

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

5.3K

Related Experiment Videos

Last Updated: Jul 12, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.4K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

5.3K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, often involving lipopolysaccharides (LPS) from Gram-negative bacteria.
  • Antibiotic therapy for sepsis faces challenges due to resistance and inability to neutralize LPS, a potent immune stimulant.
  • The COVID-19 pandemic, caused by SARS-CoV-2, presents high mortality and shares inflammatory characteristics with sepsis, including TLR4 pathway activation.

Purpose of the Study:

  • To compare and contrast sepsis and COVID-19.
  • To analyze similarities and differences at pathophysiological, epidemiological, and molecular levels.
  • To explore the role of LPS and TLR4 signaling in both conditions.

Main Methods:

  • Literature review and analysis of existing studies on sepsis and COVID-19.
  • Comparative analysis of pathophysiological mechanisms.
  • Examination of epidemiological data and molecular signaling pathways, including LPS and TLR4.

Main Results:

  • Both sepsis and severe COVID-19 exhibit significant inflammation, cytokine release, and upregulation of Toll-like receptor 4 (TLR4).
  • The inflammatory response in COVID-19 can mimic bacterial sepsis, with similar cytokine profiles and potential for bacterial co-infections.
  • LPS presence in severe COVID-19 cases highlights a shared molecular pathway with sepsis.

Conclusions:

  • COVID-19 and sepsis share critical pathophysiological and molecular similarities, particularly concerning TLR4-mediated inflammation.
  • Understanding these overlaps may inform therapeutic strategies for severe COVID-19 and sepsis.
  • Further research into the interplay of viral and bacterial factors, including LPS, is warranted.