Cecal short-chain fatty acids in experimental rabbit mucoid enteropathy

Short-chain fatty acid concentrations were measured in the cecal contents of 9 healthy rabbits and 20 rabbits with experimentally induced mucoid enteropathy. In control rabbits, cecal concentration of acetate was the most abundant, followed by that of butyrate and propionate--a feature distinguishing rabbits from most other mammals. In mucoid enteropathy, cecal acetate and butyrate concentrations were lower, whereas propionate, isobutyrate, valerate, and isovalerate were increased. The results indicated that there were abnormal fermentation and cecal maldigestion in rabbits with mucoid enteropathy.