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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The Functions of the Skeletal System01:22

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Updated: Jul 12, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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LRP5, Bone Mass Polymorphisms and Skeletal Disorders.

Jake Littman1,2, Wentian Yang1, Jon Olansen1

  • 1Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Genes
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Genetic variants in LRP5, a key protein in skeletal development, cause disorders like osteoporosis-pseudoglioma syndrome. Understanding LRP5 function is vital for treating bone diseases and skeletal abnormalities.

Keywords:
LRP5OPPGhigh bone masslow bone masslow-density lipoprotein receptor-related protein 5osteoporosis-pseudoglioma syndromeskeletal dysmorphogenesisskeletal phenotype

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Area of Science:

  • Skeletal Biology
  • Genetics
  • Molecular Biology

Background:

  • Skeletal formation relies on complex signaling pathways.
  • Genetic variations can disrupt skeletal development, leading to diseases.
  • Low-density lipoprotein receptor-related protein 5 (LRP5) is critical for skeletal homeostasis.

Purpose of the Study:

  • To review the role of LRP5 in skeletal morphogenesis.
  • To discuss skeletal structural consequences of LRP5 abnormalities.
  • To explore LRP5's potential in treating bone pathologies.

Main Methods:

  • Literature review of genetic studies on LRP5.
  • Analysis of genotype-phenotype correlations in skeletal disorders.
  • Discussion of WNT signaling pathway involvement.

Main Results:

  • Loss-of-function LRP5 variants cause osteoporosis-pseudoglioma syndrome and other low bone mass disorders.
  • Gain-of-function LRP5 variants are linked to high bone mass phenotypes.
  • LRP5 is a crucial co-receptor in the WNT-β-catenin signaling pathway.

Conclusions:

  • LRP5 plays a multifaceted role in skeletal development and maintenance.
  • Understanding LRP5 function offers therapeutic targets for osteoporosis and skeletal abnormalities.
  • Further research into LRP5 could illuminate treatments for congenital and lifelong skeletal disabilities.