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Updated: Jul 12, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
28.2K
The Human Microbiome and Its Role in Musculoskeletal Disorders.
Khaled Aboushaala1,2, Arnold Y L Wong3, Juan Nicolas Barajas1,2
1Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Genes
|October 28, 2023
Summary
Variations in gut microbiota may influence chronic musculoskeletal diseases (MSDs). Exploring the human microbiome
Area of Science:
- Microbiome research
- Human physiology
- Disease etiology
Background:
- Musculoskeletal diseases (MSDs) represent a significant global health burden.
- The gut microbiota, a complex community of microorganisms, plays a vital role in human health.
- Emerging evidence suggests a link between gut microbial composition and chronic MSDs.
Purpose of the Study:
- To review the current understanding of the human microbiome's role in musculoskeletal diseases.
- To explore the potential of microbiota-based interventions for chronic MSDs.
Main Methods:
- This is a narrative review.
- Literature search on human microbiome and musculoskeletal diseases.
Main Results:
- The gut microbiome influences host metabolism and immunity, impacting disease development.
- Alterations in gut microbial ecology are associated with various health conditions.
- Microbiota-based therapies show promise for chronic conditions.
Conclusions:
- The human microbiome is a potential therapeutic target for managing chronic musculoskeletal diseases.
- Further research into the gut microbiome's role in MSDs is warranted.
- Microbiota-based interventions may offer a novel treatment strategy for MSDs.
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