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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Skin Lesions in Diabetes Mellitus: A 6-Year Observational Study and 11-Year Longitudinal Analysis of Hospital Admissions from NE Romania.

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Correction: Yalçın et al. Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes. <i>Life</i> 2025, <i>15</i>, 722.

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Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Update on Obesity in Psoriasis Patients.

Dan Vata1,2, Bogdan Marian Tarcau1,2, Ioana Adriana Popescu1,2

  • 1Department of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Life (Basel, Switzerland)
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Psoriasis and obesity are linked, with each condition potentially causing the other. Understanding this connection, including factors like adipokines and the microbiome, may lead to new treatments for psoriasis.

Keywords:
adipokinesautoimmunemicrobiomeobesitypsoriasis

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Area of Science:

  • Dermatology
  • Immunology
  • Metabolic Diseases

Background:

  • Psoriasis is a chronic inflammatory skin disease influenced by genetic, epigenetic, environmental, and lifestyle factors.
  • Severe psoriasis significantly impacts quality of life, comparable to chronic conditions like diabetes and depression.
  • An increasing incidence of autoimmune diseases, including psoriasis, overlaps with rising obesity rates.

Purpose of the Study:

  • To explore the bidirectional relationship between psoriasis and obesity.
  • To investigate the role of adipokines and the human microbiome in the pathogenesis of psoriasis in obese individuals.

Main Methods:

  • Review of current research on psoriasis and obesity.
  • Analysis of studies investigating adipokines secreted by adipose tissue.
  • Examination of research identifying specific human microbiome patterns associated with obesity and psoriasis.

Main Results:

  • Psoriasis and obesity exhibit a two-way association, where each condition can exacerbate the other.
  • Elevated levels of specific adipokines in obese psoriasis patients suggest shared pathogenic mechanisms.
  • Distinct human microbiome patterns are identified in individuals with obesity and psoriasis.

Conclusions:

  • The interplay between psoriasis and obesity is complex, involving shared molecular pathways and microbial influences.
  • Obesity affects psoriasis treatment response and adverse events, potentially decreasing patient compliance.
  • Targeting specific microbiome patterns presents a potential future therapeutic strategy for select individuals with psoriasis and obesity.