Related Experiment Video
Updated: Jul 12, 2025
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
1.1K
The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to
Daniélle van Staden1, Richard K Haynes1,2, Joe M Viljoen1
1Faculty of Health Sciences, Centre of Excellence for Pharmaceutical Sciences (PharmacenTM), Building G16, North-West University, 11 Hoffman Street, Potchefstroom 2520, South Africa.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
Summary
This study developed novel self-double-emulsifying drug delivery systems (SDEDDSs) for dermal delivery of four anti-tubercular drugs. These systems show promise for enhanced drug penetration and stability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Dermatology
Background:
- Self-emulsifying drug delivery systems (SEDDSs) offer advantages over traditional oral systems, including drug protection and enhanced absorption.
- Recent interest in dermal applications stems from their ability to deliver drugs across skin and mucus membranes.
- Tuberculosis treatment often requires multiple drugs, posing formulation challenges.
Purpose of the Study:
- To develop and characterize a novel self-double-emulsifying drug delivery system (SDEDDS) for dermal delivery.
- To incorporate four anti-tubercular drugs: clofazimine (CFZ), isoniazid (INH), pyrazinamide (PZY), and rifampicin (RIF).
- To evaluate the potential of SDEDDS as a dermal drug delivery vehicle.
Main Methods:
- Construction of pseudoternary phase diagrams.
- Assessment of oil miscibility, self-emulsification performance, and emulsion stability.
- Solubility studies and isothermal microcalorimetry for drug compatibility.
- Microscopic examination of the developed emulsions.
Main Results:
- Successful development of a double spontaneous emulsion incorporating four anti-tubercular drugs.
- Demonstrated potential of SDEDDS as a dermal drug delivery vehicle.
- Preformulation studies were crucial for successful SDEDDS development.
Conclusions:
- The study successfully produced SDEDDSs capable of incorporating four individual anti-tubercular drugs.
- SDEDDSs show significant potential for dermal drug delivery applications.
- Preformulation studies are essential for the successful development of dermal SDEDDSs.
Related Concept Videos
01:16Drug Delivery: Overview
300
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
300
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
136
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
136
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
209
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
209
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
864
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
864
01:28Preclinical Development: Overview
4.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.5K
01:09Methods for Studying Drug Absorption: In situ
244
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
244