Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

1.6K
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.6K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

424
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
424
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

561
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
561
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

925
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
925
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

706
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
706

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Ia antibodies: a revolutionary therapy for immune-mediated diseases?

Immunology today·2014
Same author

The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells.

Immunology today·2014
Same author

Mitrecin A, an endolysin-like bacteriolytic enzyme from a newly isolated soil streptomycete.

Letters in applied microbiology·2014
Same author

[The effect of Soviet synthetic antimalarial remedies, acriquine and plasmocide, on the nervous system].

Farmakologiia i toksikologiia·2010
Same author

Immune cell cooperation, viruses, and antibodies to nucleic acids in new zealand mice.

The Journal of experimental medicine·2009
Same author

Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: long-term followup of a cohort of 145 patients participating in randomized controlled studies.

Arthritis and rheumatism·2002
Same journal

The Role of Telemedicine on Interhospital Transfer Outcomes : A Systematic Review.

Annals of internal medicine·2026
Same journal

Prolonged Short Sleep and Its Effect on Body Weight and Composition : A Pooled Analysis of Randomized Trials.

Annals of internal medicine·2026
Same journal

In AF, LAAC was noninferior to NOAC therapy for a composite efficacy outcome and reduced non-procedure-related bleeding at 3 y.

Annals of internal medicine·2026
Same journal

How AI is affecting medical journals.

Annals of internal medicine·2026
Same journal

In adults with COPD, the BLISS score predicted risk for acute respiratory hospital admission at 2 y.

Annals of internal medicine·2026
Same journal

In AF at risk for stroke and bleeding, LAAC was not noninferior to medical therapy for a composite of thromboembolic and safety events.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.7K

NIH conference. Lupus nephritis.

J E Balow, H A Austin, G C Tsokos

    Annals of Internal Medicine
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Lupus nephritis, a severe kidney complication of systemic lupus erythematosus, involves immune complex and lymphoid cell accumulation. Certain cytotoxic drug regimens offer better treatment outcomes than corticosteroids alone for lupus nephritis.

    More Related Videos

    Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
    09:43

    Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

    Published on: June 8, 2022

    2.6K
    Murine Bilateral Renal Lymphadenectomy
    06:31

    Murine Bilateral Renal Lymphadenectomy

    Published on: December 30, 2025

    227

    Related Experiment Videos

    Last Updated: May 6, 2026

    The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
    12:04

    The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

    Published on: November 1, 2015

    17.7K
    Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
    09:43

    Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

    Published on: June 8, 2022

    2.6K
    Murine Bilateral Renal Lymphadenectomy
    06:31

    Murine Bilateral Renal Lymphadenectomy

    Published on: December 30, 2025

    227

    Area of Science:

    • Nephrology
    • Immunology
    • Rheumatology

    Background:

    • Lupus nephritis is a critical manifestation of systemic lupus erythematosus (SLE).
    • Kidney pathology in lupus nephritis is characterized by immune complex and lymphoid cell deposition.
    • The heterogeneity of renal changes suggests multifactorial pathogenesis.

    Purpose of the Study:

    • To review the pathogenesis and treatment of lupus nephritis.
    • To highlight the challenges in classifying human lupus nephritis based on pathogenetic mechanisms.
    • To evaluate therapeutic strategies for lupus nephritis.

    Main Methods:

    • Utilized inbred strains of lupus-prone mice for controlled studies.
    • Reviewed existing literature on lupus nephritis pathology and treatment.
    • Analyzed the comparative efficacy of different therapeutic regimens.

    Main Results:

    • Immune complex and lymphoid cell accumulation are key features of lupus nephritis.
    • Mouse models offer a homogeneous system for studying disease mechanisms.
    • Cytotoxic drugs demonstrate superior efficacy compared to corticosteroids in managing lupus nephritis.

    Conclusions:

    • Lupus nephritis is a complex renal disease with diverse pathological findings.
    • Accurate classification of human lupus nephritis is hindered by incomplete understanding of its etiology.
    • Combination therapy with cytotoxic agents represents an advancement in lupus nephritis treatment.