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Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

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Updated: Jul 12, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogel-Based Microneedle as a Drug Delivery System.

David Filho^1,2, Marcelo Guerrero^1,2, Manuel Pariguana^1,2

¹Laboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, Chile.

|October 28, 2023

Summary

This summary is machine-generated.

Hydrogels and microneedles combine for advanced transdermal drug delivery systems (TDDS). This innovative approach offers controlled, localized drug release, enhancing therapeutic outcomes and treatment possibilities.

Keywords:

biomedical applications delivery systems hydrogels microneedles

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Published on: November 17, 2015

Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

The skin, as the largest organ, offers accessible routes for noninvasive drug administration via transdermal drug delivery systems (TDDS).
Hydrogels (HG) and microneedles (MNs) are key components in advanced drug delivery technologies.

Purpose of the Study:

To explore the application of combining hydrogels and microneedles (HG-MNs) for enhanced drug delivery.
To detail the advantages offered by HG-MN systems in transdermal administration.

Main Methods:

Investigating the properties of hydrogel matrices and their interaction with microneedle technology.
Analyzing the characteristics of HG-MN systems for drug delivery applications.

Main Results:

HG-MNs exhibit advantageous properties, including responsiveness to external stimuli, derived from their hydrogel components.
These systems enable controlled, sustained, and localized drug release.
The combination allows for synergistic interactions between formulation components and multiple bioactive agents.

Conclusions:

HG-MN based systems present significant advantages in the biomedical field.
This technology offers a novel and safe platform for improving drug pharmacokinetics and pharmacodynamics.
HG-MNs open new perspectives for drug treatment strategies.