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Technological Interventions Enhancing Curcumin Bioavailability in Wound-Healing Therapeutics
Hemant Singh1,2,3,4, Mukesh Dhanka2, Indu Yadav1
1Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, India.
Tissue Engineering. Part B, Reviews
|October 28, 2023
Summary
Curcumin, a natural compound, shows promise for wound healing but has low bioavailability. Advanced carrier systems like nanoparticles and hydrogels enhance curcumin
Area of Science:
- Biomaterials Science
- Pharmacology
- Tissue Engineering
Background:
- Wound healing remains a significant medical challenge, driving research into novel therapeutic formulations.
- Herbal components are increasingly favored in advanced wound healing formulations due to their natural origin and therapeutic properties.
- Curcumin, derived from turmeric, possesses potent antioxidant, antimicrobial, and anti-inflammatory properties beneficial for healing, but suffers from poor solubility and stability.
Purpose of the Study:
- To review recent advancements in curcumin-based formulations for wound healing.
- To explore the mechanisms of action of curcumin in wound repair.
- To discuss the application of these advanced formulations across different stages of the wound healing process.
Main Methods:
- Review of current literature on curcumin formulations for wound healing.
- Analysis of various carrier systems including nanoparticles, hydrogels, scaffolds, films, fibers, and nanoemulgels.
- Examination of curcumin's therapeutic effects and mechanisms in the context of wound repair.
Main Results:
- Curcumin's therapeutic potential is significantly enhanced by advanced delivery systems.
- Nanoparticles, hydrogels, and other matrices improve curcumin's bioavailability and stability.
- These formulations demonstrate efficacy in promoting wound healing through antioxidant, anti-inflammatory, and antimicrobial actions.
Conclusions:
- Advanced carrier systems are crucial for overcoming curcumin's limitations in wound healing applications.
- Tissue engineering approaches offer innovative strategies for effective curcumin delivery and utilization.
- Curcumin-based formulations hold considerable promise for accelerating and improving wound healing outcomes.
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