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Sara Sommer Holst1, Kristian Karstoft1, Mikkel Erik Juul Jensen2

  • 1Klinisk Farmakologisk Afdeling, Københavns Universitetshospital - Bispebjerg og Frederiksberg Hospital.

Ugeskrift for Laeger
|October 28, 2023
PubMed
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Defining polypharmacy remains a challenge, with no universal agreement. This review examines common definitions and highlights the need to distinguish between appropriate and inappropriate medication use.

Area of Science:

  • Gerontology
  • Pharmacology
  • Public Health

Background:

  • Polypharmacy, the concurrent use of multiple medications, lacks a universally accepted definition.
  • Existing definitions often rely on arbitrary thresholds, such as using five or more drugs simultaneously.
  • This ambiguity complicates research and clinical practice concerning medication management in diverse patient populations.

Approach:

  • This review synthesizes common definitions of polypharmacy found in scientific literature.
  • It critically analyzes the challenges associated with establishing a single, suitable definition.
  • The review emphasizes the importance of context when interpreting polypharmacy definitions.

Key Points:

  • The most prevalent definition of polypharmacy involves the simultaneous use of five or more medications.

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  • Polypharmacy is associated with an increased risk of adverse health outcomes.
  • A critical distinction is needed between appropriate and inappropriate polypharmacy, as high medication use is not always excessive.

    • Conclusions:

    • A universal definition for polypharmacy has not yet been established.
    • Future research and clinical guidelines must acknowledge the varied definitions used in existing literature.
    • Definitions should ideally differentiate between beneficial and detrimental medication regimens to guide clinical decision-making.