Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleredema in an infant.

B Heilbron, N Saxe

    Archives of Dermatology
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Scleredema in an infant, linked to cytomegalovirus pneumonia, proved rapidly fatal. Histologic diagnosis is crucial for differentiating scleredema from similar conditions, with cetylpyridinium chloride aiding in visualizing acid mucopolysaccharides.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Validation of the U.K. Working Party diagnostic criteria for atopic eczema in a Xhosa-speaking African population.

    The British journal of dermatology·2007
    Same author

    Poikiloderma, tendon contracture and pulmonary fibrosis: a new autosomal dominant syndrome?

    The British journal of dermatology·2006
    Same author

    Warnings on the use of isotretinoin.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1999
    Same author

    Malignant melanoma in Cape Town, South Africa.

    The British journal of dermatology·1998
    Same author

    The natural history and rate of progression of aortic stenosis.

    Chest·1998
    Same author

    Dermatology in South Africa.

    Archives of dermatology·1995
    Same journal

    Scoring With SCORTEN-Reply.

    Archives of dermatology·2017
    Same journal

    Comparison of Early and Late Latent Syphilis- Colorado, 1991.

    Archives of dermatology·2016
    Same journal

    Case of Rhinoscleroma.

    Archives of dermatology·2016
    Same journal

    Cutaneous Fungal Infections.

    Archives of dermatology·2016
    Same journal

    An Ulcerated Plaque in a Gay Man.

    Archives of dermatology·2016
    Same journal

    Solitary Violaceous Nodule on the Face.

    Archives of dermatology·2016
    See all related articles

    Area of Science:

    • Pediatric Pathology
    • Dermatopathology
    • Infectious Diseases

    Background:

    • Scleredema is a rare, indurative skin condition affecting connective tissue.
    • Distinguishing scleredema from similar pediatric dermatoses like scleredema neonatorum, subcutaneous fat necrosis, and scleroderma can be challenging.
    • Cytomegalovirus (CMV) infections can present with diverse clinical manifestations in infants.

    Observation:

    • A 3-month-old infant presented with scleredema.
    • The infant also had cytomegalovirus pneumonia.
    • The clinical course was rapidly fatal.

    Findings:

    • Histologic examination is essential for accurate diagnosis of scleredema.
    • Cetylpyridinium chloride proved effective as a histological fixative.

    Related Experiment Videos

  • This fixative facilitated the demonstration of acid mucopolysaccharides in the affected tissue.

    • Implications:

    • Accurate histologic diagnosis is critical for managing infants with scleredema and associated infections.
    • The use of cetylpyridinium chloride offers a reliable method for identifying key histological features.
    • This case highlights the severe potential of combined scleredema and CMV pneumonia in neonates.