Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

164
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
164
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

192
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
192
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

2.6K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
2.6K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

431
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
431

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Duality of Bacteroides cross-feeding networks in health and disease.

Pharmacological research·2026
Same author

Testosterone Therapy After Radical Prostatectomy: Insights From a Systematic Review and Meta-Analysis.

Andrology·2026
Same author

Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.

EBioMedicine·2026
Same author

A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials.

The journal of sexual medicine·2026
Same author

Tooth Transplantation With Sticky Bone for Vertical Bone Defects: A 4-Year Follow-Up Case Report.

Case reports in dentistry·2026
Same author

Correction: Penile prosthesis implantation: a systematic review of intraoperative and postoperative complications.

International journal of impotence research·2026

Related Experiment Video

Updated: Jul 12, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

677

Penile implants in low flow priapism.

Musaab Yassin1,2, Runzhi Chen3, Michael Ager4

  • 1Department of Urology, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK. Musaab.Yassin@ouh.nhs.uk.

International Journal of Impotence Research
|October 29, 2023
PubMed
Summary
This summary is machine-generated.

Penile implants can restore erectile function in low-flow priapism but pose surgical challenges. Patient counseling on risks, benefits, and managing complications is crucial for satisfaction.

More Related Videos

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

18.9K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.4K

Related Experiment Videos

Last Updated: Jul 12, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

677
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

18.9K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.4K

Area of Science:

  • Urology
  • Andrology
  • Sexual Medicine

Background:

  • Priapism, particularly prolonged ischemic (low-flow) priapism, can lead to corporal fibrosis and long-term erectile dysfunction.
  • Penile prosthesis implantation is an effective treatment for restoring erectile function in refractory and delayed low-flow priapism.
  • Fibrotic scarring in the corpora cavernosa presents surgical challenges and potential complications during penile implant surgery.

Purpose of the Study:

  • To review the existing literature on penile implants for managing priapism.
  • To discuss the challenges and options for managing complications associated with penile prosthesis surgery in priapism patients.
  • To highlight the importance of patient counseling regarding risks, benefits, and outcomes.

Main Methods:

  • Comprehensive literature review of studies on penile implants in patients with priapism.
  • Analysis of surgical challenges, complication rates, and patient satisfaction.
  • Discussion of prosthesis choice and procedural timing.

Main Results:

  • Penile implants offer high patient satisfaction rates for erectile function restoration in priapism.
  • Surgical complications are more frequent in patients with corporal fibrotic scarring.
  • Patient satisfaction is linked to preoperative expectations and perceived penile length changes.

Conclusions:

  • Penile prosthesis implantation is a viable option for priapism, but careful surgical technique and patient selection are essential.
  • Thorough preoperative counseling is critical to manage patient expectations and improve satisfaction.
  • Further consensus is needed on optimal prosthesis selection and surgical timing for refractory low-flow priapism.