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Updated: Aug 2, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
[So-called reticulohistiocytic granulomatous encephalitis]
Abstract:
On the basis of clinicomorphological study of 4 observations the authors outline a specific form of granulomatous encephalitis known from the literature as "reticulohistiocytic granulomatous encephalitis". The disease occurs at any age. Its course may be chronic or subacute, less frequently--acute. The process may localize anywhere, with predominant occurrence of the lesion in the periventricular region of the third ventricle. The morphological feature of this encephalitic form is a formation of large foci and microgranulomas from lymphocytes, histiocytes, macrophages, epithelioid cells and microgliacytes. The variants of granulomatous encephalitis distinguished by the ratio of the above-mentioned cellular elements should be considered as an etiologically heterogenic group of inflammatory brain diseases, that are likely to develop due to delayed hypersensitivity.
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