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Updated: Aug 2, 2026
10:50
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
[So-called reticulohistiocytic granulomatous encephalitis]
Arkhiv Patologii
|January 1, 1986
Summary
This study identifies reticulohistiocytic granulomatous encephalitis, a brain inflammation characterized by specific cell types. It suggests this condition may arise from delayed hypersensitivity reactions.
Area of Science:
- Neurology
- Pathology
Background:
- Granulomatous encephalitis represents a group of inflammatory brain diseases.
- Reticulohistiocytic granulomatous encephalitis is a specific, though less common, form.
Observation:
- Clinicomorphological study of 4 cases.
- Disease affects any age with variable course (chronic, subacute, acute).
- Lesions often occur in the periventricular region of the third ventricle.
Findings:
- Morphological hallmark: large foci and microgranulomas composed of lymphocytes, histiocytes, macrophages, epithelioid cells, and microgliacytes.
- Disease variants reflect differing cellular compositions.
- Etiologically heterogeneous group of inflammatory brain diseases.
Implications:
- Suggests a potential link to delayed hypersensitivity.
- Highlights the need for further research into the etiology and pathogenesis.
- Informs differential diagnosis of granulomatous brain lesions.
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