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Updated: Jul 12, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

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Tailored biomedical materials for wound healing.

Wenhui Liu^1,2, Lihua Zu¹, Shanzheng Wang³

¹Clinical laboratory, Affiliated Aoyang Hospital of Jiangsu University, 279 Jingang Road, Suzhou, Jiangsu, China.

|October 30, 2023

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Smart biomaterials precisely control wound healing stages, managing inflammation and infection while promoting tissue regeneration for improved wound therapy. This review details their design and applications.

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Research

Background:

Wound healing is a complex, multi-stage biological process involving hemostasis, inflammation, proliferation, and remodeling.
Effective wound management requires controlling infection and inflammation while promoting tissue regeneration.
Smart biomaterials offer precise temporal and spatial control over the wound healing cascade.

Purpose of the Study:

To review the design strategies of smart biomaterials for wound healing.
To highlight the precise control biomaterials offer across different wound healing phases.
To outline the clinical and practical applications of advanced biomaterials in wound therapy.

Main Methods:

Literature review of biomaterial design approaches for wound healing.

Keywords:

Advanced materials Anti-bacterial Biomedical materials Cutaneous injury Inflammation Regeneration Tissue regeneration Wound healing

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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

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Analysis of biomaterial strategies for anti-inflammatory, antimicrobial, and tissue regenerative applications.

Synthesis of information on advanced control mechanisms and clinical applications.

Main Results:

Biomaterials can be designed to target specific stages of wound healing, including inflammation control and infection prevention.
Advanced biomaterials enable precise modulation of the biological environment to promote tissue regeneration.
Significant progress has been made in the clinical and practical application of smart biomaterials for wound therapy.

Conclusions:

Smart biomaterials represent a significant advancement in wound healing, offering tailored therapeutic interventions.
Understanding biomaterial design principles facilitates personalized material development for diverse wound types.
The review underscores the potential of biomaterials to revolutionize wound care through precise, stage-specific control.