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Related Experiment Video

Updated: Jul 12, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis.

Yanpeng Wang1, Yinzhen Zhang1, Changwei Zhao2

  • 1Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.

Iranian Journal of Public Health
|October 30, 2023
PubMed
Summary

Watching TV increases osteoarthritis risk, particularly for knees and spine. Body Mass Index (BMI) and smoking mediate this link, suggesting interventions can reduce osteoarthritis burden.

Keywords:
LifestyleMendelian randomizationOsteoarthritisSedentary behavior

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Area of Science:

  • Epidemiology
  • Genetics
  • Public Health

Background:

  • The relationship between sedentary behavior, physical activity, and osteoarthritis remains unclear.
  • Understanding these links is crucial for developing effective osteoarthritis prevention strategies.

Purpose of the Study:

  • To investigate the causal effects of physical activity and sedentary behavior on osteoarthritis.
  • To explore potential mediating factors in the relationship between sedentary behavior and osteoarthritis.

Main Methods:

  • Two-sample Mendelian randomization analysis using single nucleotide polymorphisms (SNPs) as instrumental variables.
  • Two-step Mendelian randomization was employed to assess the mediating roles of BMI, smoking, and Apolipoprotein B.

Main Results:

  • TV watching showed a causal association with increased risk of knee osteoarthritis (OR=1.162) and spine osteoarthritis (OR=1.208).
  • Body Mass Index (BMI) significantly mediated the effect of TV watching on both knee (47.1%) and spine (29.5%) osteoarthritis.
  • Smoking also mediated the association between TV watching and spine osteoarthritis (16.1%).

Conclusions:

  • TV watching is identified as a potential risk factor for developing osteoarthritis.
  • Modifiable factors like BMI and smoking play a mediating role, offering targets for intervention.
  • Interventions focused on BMI and smoking cessation could mitigate osteoarthritis risk associated with prolonged TV viewing.