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Related Experiment Video

Updated: Jul 12, 2025

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

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Published on: October 30, 2010

55.3K

Kidney Biopsy Corner: Amyloidosis.

Laura E Biederman1,2, Alana D Dasgupta1, Darren E Dreyfus3

  • 1Department of Pathology, Ohio State Wexner Medical Center, Columbus, OH, USA.

Glomerular Diseases
|October 30, 2023
PubMed
Summary

AA amyloidosis, a kidney disease from misfolded proteins, can affect individuals with a history of intravenous drug abuse. This case highlights the diverse kidney amyloidosis types and their clinical presentations.

Keywords:
AA amyloidosisAmyloidosisIntravenous drug useKidney biopsyMass spectrometry

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Area of Science:

  • Nephrology
  • Pathology
  • Protein misfolding diseases

Background:

  • Amyloidosis is characterized by the deposition of misfolded proteins in various organs.
  • Kidney involvement in amyloidosis can manifest in diverse patterns and clinical settings.
  • Fourteen distinct types of amyloidosis are recognized by the International Society of Amyloidosis, each with unique characteristics.

Purpose of the Study:

  • To report a case of AA amyloidosis in a young male with a history of intravenous drug abuse.
  • To provide a comprehensive review of the different types of amyloidosis that can affect the kidney.
  • To enhance understanding of the varied presentations and implications of renal amyloidosis.

Main Methods:

  • Case report of a 24-year-old male with AA amyloidosis.
  • Literature review of amyloidosis types involving the kidney.
  • Analysis of clinical presentation and pathological findings.

Main Results:

  • The case presented AA amyloidosis in a patient with a history of intravenous drug abuse.
  • A review of 14 amyloidosis types affecting the kidney was conducted.
  • Different amyloid types exhibit varied locations and clinical associations.

Conclusions:

  • AA amyloidosis can occur in younger individuals, particularly those with risk factors like intravenous drug abuse.
  • Recognizing the diverse forms of kidney amyloidosis is crucial for accurate diagnosis and management.
  • Further research into the specific mechanisms and treatments for different amyloidosis subtypes is warranted.