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Updated: Jul 12, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Minimum regularized covariance determinant and principal component analysis-based method for the identification of
Siti Zahariah1,2, Habshah Midi2,3
1Applied Statistics and Data Science Cluster, Universiti Kuala Lumpur Malaysian Institute of Information Technology (UniKL MIIT), Kuala Lumpur, Malaysia.
Abstract:
The main aim of this paper is to propose a novel method (RMD-MRCD-PCA) of identification of High Leverage Points (HLPs) in high-dimensional sparse data. It is to address the weakness of the Robust Mahalanobis Distance (RMD) method which is based on the Minimum Regularized Covariance Determinant (RMD-MRCD), which indicates a decrease in its performance as the number of independent variables (p) increases. The RMD-MRCD-PCA is developed by incorporating the Principal Component Analysis (PCA) in the MRCD algorithm whereby this robust approach shrinks the covariance matrix to make it invertible and thus, can be employed to compute the RMD for high dimensional data. A simulation study and two real data sets are used to illustrate the merit of our proposed method compared to the RMD-MRCD and Robust PCA (ROBPCA) methods. Findings show that the performance of the RMD-MRCD is similar to the performance of the RMD-MRCD-PCA for p close to 200. However, its performance tends to decrease when the number of p is more than 200 and worsens at p equals 700 and larger. On the other hand, the ROBPCA is not effective for less than 20% contamination as it suffers from serious swamping problems.
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