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Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices

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Woven Endo Bridge shape modification contributes to decrease in adequate occlusion rate after Woven Endo Bridge

Takashi Fujii¹, Kohsuke Teranishi², Takayuki Kitamura²

¹Department of Neuroendovascular Therapy, Juntendo University, Graduate School of Medicine, Tokyo, Japan.

The Neuroradiology Journal

|October 30, 2023

Summary

Woven Endo Bridge (WEB) device implantation for wide-neck bifurcation intracranial aneurysms achieved 75.9% adequate occlusion. WEB shape modification was the sole factor impacting non-occlusion, necessitating further investigation for improved outcomes.

Keywords:

Intracranial aneurysm Woven Endo Bridge Woven Endo Bridge shape modification flow disruptor

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Published on: May 11, 2011

Area of Science:

Neurosurgery
Interventional Neuroradiology
Medical Devices

Background:

Wide-neck bifurcation intracranial aneurysms (WNBAs) pose treatment challenges.
The Woven Endo Bridge (WEB) device offers a novel endovascular solution for WNBAs.
Assessing factors influencing WEB device efficacy is crucial for optimizing patient outcomes.

Purpose of the Study:

To identify radiological factors associated with adequate occlusion (AO) after WEB device implantation for WNBAs.
To evaluate the safety and efficacy of the WEB device in treating WNBAs.
To determine predictors of successful aneurysm occlusion using detailed imaging analysis.

Main Methods:

Retrospective analysis of 29 patients with WNBAs treated with WEB device implantation.
Comparison of radiological parameters between patients achieving AO and those with non-AO.
Multivariate analysis to identify significant contributing factors to AO.

Main Results:

Adequate occlusion (AO) was achieved in 75.9% of patients at 6-month follow-up.
Complications were infrequent (6.9%) and did not significantly alter functional status (mRS).
WEB shape modification (WSM) was the only statistically significant factor associated with non-AO (OR: 0.912, p=0.0287).

Conclusions:

WEB device implantation is an effective and safe treatment for WNBAs.
WEB shape modification is a critical factor influencing treatment success.
Further research is needed to understand and mitigate WSM for improved AO rates.