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Published on: January 29, 2018
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Association between urine caffeine metabolites and bone mineral density: A population-based study
Ning Tan1, Wenjia Shen2, Meiling Tang3
1Department of Urology, The Affiliated Second Hospital, Hengyang Medical school, University of South China, Hengyang, China.
Medicine
|October 31, 2023
Summary
This study found no significant link between urine caffeine levels and bone mineral density (BMD) in U.S. adults. Further research is needed to explore potential U-shaped relationships and underlying mechanisms.
Area of Science:
- Epidemiology
- Nutritional Science
- Bone Health Research
Background:
- The relationship between coffee consumption and bone mineral density (BMD) is debated.
- The connection between urinary caffeine and its metabolites and BMD has not been previously investigated.
Purpose of the Study:
- To examine the association between urinary caffeine and its metabolites with BMD in U.S. adults.
- To explore potential gender and ethnic differences in this relationship.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2009-2014.
- Employed multivariate linear and logistic regression models.
- Applied fitted smoothing curves and generalized additive models for analysis.
Main Results:
- No significant association was found between urinary caffeine/metabolites and overall BMD after adjusting for covariates.
- Subgroup analyses by gender and ethnicity did not alter the consistency of this finding.
- Identified potential inflection points for U-shaped relationships between urinary theophylline/paraxanthine and BMD.
Conclusions:
- This cross-sectional study found no significant correlation between urinary caffeine, its metabolites, and BMD.
- Further investigation is warranted to confirm these findings and elucidate potential mechanisms.
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