Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Responses to Heat and Cold Stress

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Italian Olfactory Identification Test in Systemic Lupus Erythematosus: Association of Olfactory Impairment With Chronic Damage and Anti-β<sub>2</sub>-Glycoprotein I Antibodies.

ACR open rheumatology·2026

Same author

Idebenone in Rapid Eye Movement Sleep Behavioral Disorder for Parkinson's Disease Prevention.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

Prenatal exercise interventions result in subtle changes in the human breast milk metabolome and lipidome 7-14 days postpartum: exploratory analyses of the FitMum randomized controlled trial.

International breastfeeding journal·2026

Same author

Isolation of Extracellular Vesicles From Mouse Brown Adipose Tissue Secretome Using Size-Exclusion Chromatography.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

Distinct Effects of Maternal Stress and Exercise on Offspring Metabolic Health.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

Caregiver burden of parkinsonian patients with impulse control disorders, depression and apathy.

Journal of neural transmission (Vienna, Austria : 1996)·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue.

Maria Vamvini^1,2, Pasquale Nigro¹, Tiziana Caputo¹

¹Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA.

Biorxiv : the Preprint Server for Biology

|October 31, 2023

Summary

Exercise training improves glucose metabolism by altering inguinal white adipose tissue (iWAT), while cold exposure enhances thermogenesis but not glucose control. Trained iWAT uniquely mediates metabolic benefits through tissue communication.

Keywords:

adipose tissue cold exercise proteomics secretome transplantation

More Related Videos

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Related Experiment Videos

Last Updated: Jul 8, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Area of Science:

Metabolic Health
Adipose Tissue Biology
Proteomics

Background:

Exercise training and cold exposure are known to improve systemic metabolism.
The precise molecular mechanisms underlying these metabolic improvements, particularly adaptations in inguinal white adipose tissue (iWAT), remain incompletely understood.

Approach:

Investigated the impact of exercise-trained and cold-exposed iWAT on systemic glucose metabolism in mice via tissue transplantation.
Analyzed the proteome and secretome of iWAT following exercise training and cold exposure.
Correlated specific protein changes with metabolic outcomes, such as glucose tolerance and fasting glucose levels.

Key Points:

Transplantation of exercise-trained iWAT significantly improved glucose tolerance in sedentary mice.
Cold-exposed iWAT transplantation did not confer similar glucose metabolism benefits, despite causing more extensive proteomic alterations and boosting thermogenic capacity.
Exercise training uniquely upregulated proteins associated with extracellular space, vesicle transport, and favorable fasting glucose, suggesting distinct mechanisms for metabolic communication.

Conclusions:

Exercise training and cold exposure induce distinct adaptations in iWAT at the proteomic and secretomic levels.
Trained iWAT plays a critical role in mediating exercise-induced improvements in systemic glucose metabolism.
These findings reveal unique molecular pathways by which exercise and cold exposure impact metabolic health.