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Related Concept Videos

Anatomical Terminology01:20

Anatomical Terminology

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Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Structural Organization of the Human Body: An Overview01:18

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
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Loose Connective Tissue01:26

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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
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Regional Terms01:12

Regional Terms

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Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
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Overview of Anatomy and Physiology01:24

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Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...
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Functional Tissue Units in the Human Reference Atlas.

Supriya Bidanta1, Katy Börner1, Bruce W Herr1

  • 1Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN 47408, USA.

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|October 31, 2023
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Summary
This summary is machine-generated.

This study catalogs 22 functional tissue units (FTUs) across 10 human organs, providing detailed anatomical and cellular data. This resource aids in understanding organ function and disease, contributing to the Human Reference Atlas.

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Area of Science:

  • Anatomical sciences
  • Cellular biology
  • Physiology

Background:

  • Functional tissue units (FTUs) are fundamental to organ structure and function.
  • Understanding FTUs is crucial for modeling healthy physiology and disease pathogenesis.
  • A comprehensive catalog of human FTUs is currently lacking.

Approach:

  • Developed the first comprehensive catalog of 22 nested functional tissue units (FTUs).
  • Documented anatomical definitions, physical dimensions, vasculature, and cellular composition for FTUs in 10 healthy human organs.
  • Created datasets, illustrations, an interactive online FTU explorer, and a printable poster.

Key Points:

  • Catalog details 22 anatomically correct, nested FTUs from 10 healthy human organs.
  • Includes data on physical dimensions, vasculature, and cellular makeup of each FTU.
  • Resources like datasets, illustrations, and an online explorer are freely available.

Conclusions:

  • This FTU catalog provides a foundational resource for organ biology research.
  • Facilitates the study of organ function, disease mechanisms, and the development of the Human Reference Atlas.
  • Enables standardized analysis and modeling of human organ systems.