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Related Experiment Video

Updated: Jul 12, 2025

On-Chip Endothelial Inflammatory Phenotyping
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Inflammatory stress-mediated chromatin changes underlie dysfunction in endothelial cells.

Haibo Liu1, Amada D Caliz2, Heather Learnard3

  • 1Molecular, Cell and Cancer Biology Department, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Biorxiv : the Preprint Server for Biology
|October 31, 2023
PubMed
Summary

Inflammatory stresses alter endothelial cell chromatin, impacting cardiovascular health. This study reveals changes in centromere association with nucleoli and increased pericentromeric gene transcription during stress.

Keywords:
TNF-alphacentromereschromatincytokinesfebrileheat stressheterochromatininflammationstressvascular endothelial cells

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Area of Science:

  • Cardiovascular Biology
  • Epigenetics
  • Cellular Stress Response

Background:

  • Inflammatory stresses are implicated in endothelial dysfunction and chronic cardiovascular diseases like atherosclerosis.
  • While the transcriptional response of endothelial cells to inflammation is known, the impact on chromatin architecture remains understudied.
  • Tumor Necrosis Factor-alpha (TNF-alpha) is a key pro-inflammatory cytokine affecting endothelial cells.

Conclusions:

  • Chromatin alterations occur in vascular endothelial cells during inflammatory stress.
  • Changes in centromere localization and pericentromeric transcription suggest a novel mechanism linking inflammation, chromatin dynamics, and endothelial dysfunction.
  • These findings provide new insights into the epigenetic regulation of cardiovascular disorders.