Bioinspired and Biomimetic Gene Delivery Systems

Area of Science:

• Biomedical Engineering
• Gene Therapy Delivery Systems

Background:

• Gene therapy offers potential for treating genetic diseases by modulating gene expression.
• Current gene therapeutics face challenges like poor bioavailability, targeting, cellular uptake, and transfection efficiency.

Purpose of the Study:

• To summarize recent advancements in bioinspired and biomimetic gene delivery systems.
• To highlight the advantages of these systems in overcoming biological barriers.
• To discuss challenges and future directions for rational design.

Main Methods:

• Review of bioinspired and biomimetic strategies for gene delivery.
• Analysis of systems mimicking viruses, bacteria, exosomes, and eukaryotic cells.
• Evaluation of enhanced pharmacokinetic profiles and target cell delivery.

Main Results:

• Bioinspired and biomimetic systems show promise in overcoming gene delivery barriers.
• These platforms improve bioavailability, biocompatibility, and site-specific accumulation.
• Successful recapitulation of natural biological functions enhances therapeutic outcomes.

Conclusions:

• Bioinspired and biomimetic delivery systems are crucial for advancing gene therapy.
• These approaches amplify therapeutic efficacy and minimize adverse effects.
• Further rational design is needed to accelerate clinical translation of gene therapy.