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Updated: Aug 12, 2026

Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

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Published on: January 8, 2019

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Kaige Chen1,2,3, Quanyin Hu1,2,3,4

  • 1Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 11, 2026
PubMed
Summary

Antibody-associated targeted chimeras (AbTACs) leverage antibodies for targeted protein degradation. This review explores AbTAC evolution, platforms, and design principles for next-generation biologic degraders.

Keywords:
antibody engineeringantibody‐associated targeted chimerasprogrammable degraderstargeted protein degradation

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