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Impacts of Matrix Metalloproteinase 9 Genotypes on Renal Cell Carcinoma

Cheng-Hsi Liao1,2,3, Chung-Lin Tsai3,4, Shu-Yu Chang1,3,5

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

In Vivo (Athens, Greece)
|October 31, 2023
PubMed
Abstract

Insights

The matrix metalloproteinase 9 (MMP9) rs3918242 genotype does not directly increase renal cell carcinoma risk. However, the T allele may predict higher risk in patients with hypertension, diabetes, or a family cancer history.

Area of Science:

  • Genetics and Oncology
  • Molecular Biology
  • Cancer Epidemiology

Background:

  • Elevated matrix metalloproteinase 9 (MMP9) expression is linked to renal diseases, including renal cell carcinoma (RCC).
  • The specific role of MMP9 genetic variations, particularly promoter polymorphisms, in RCC development is not well-defined.
  • Investigating MMP9 genotypes may offer insights into RCC susceptibility.

Purpose of the Study:

  • To examine the association between the MMP9 promoter rs3918242 polymorphism and the risk of developing renal cell carcinoma.
  • To determine if specific MMP9 genotypes modify RCC risk in conjunction with clinical factors.

Main Methods:

  • Genotyping of the MMP9 rs3918242 polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • Case-control study design involving 118 RCC patients and 590 healthy controls.
  • Statistical analysis included odds ratio calculation and assessment of genotype associations with clinical parameters.

Main Results:

  • No significant association was found between MMP9 rs3918242 genotypes (CT or TT) and overall RCC risk compared to the CC genotype.
  • A significantly higher prevalence of RCC was observed in individuals with CT or TT genotypes who also had hypertension, diabetes, or a family history of cancer.
  • No correlations were identified between MMP9 rs3918242 genotype distribution and age, sex, smoking, or alcohol consumption.

Conclusions:

  • The MMP9 rs3918242 T allele may serve as a predictive marker for increased renal cell carcinoma risk.
  • This heightened risk is particularly relevant for individuals with co-existing hypertension, diabetes, or a personal/family history of cancer.
  • Further research is warranted to elucidate the mechanisms underlying gene-environment interactions in RCC pathogenesis.
Keywords:
GenotypeMMP9Taiwanpolymorphismrenal cell carcinoma

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