Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

13.3K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
13.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneously Quantifying<i>K</i><sub>1</sub>,<i>k</i><sub>2</sub>, and Blood Volume in Myocardial Imaging with Overlapping Volumes of Interest: Practical Identifiability.

Physics in medicine and biology·2026
Same author

Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.

Journal of the Endocrine Society·2026
Same author

Single-Stage Lesion Identification in $^{68}$Ga-DOTATATE PET Images.

IEEE transactions on bio-medical engineering·2026
Same author

Energy Scale-Factor Estimation for Use in Photomultiplier Tube Energy Calibration Using C-SPECT.

IEEE transactions on radiation and plasma medical sciences·2025
Same author

Multimodality assessment of the coronary microvasculature with TIMI frame count versus perfusion PET highlights coronary changes characteristic of coronary microvascular disease.

Frontiers in cardiovascular medicine·2024
Same author

Improving Generalizability of PET DL Algorithms: List-Mode Reconstructions Improve DOTATATE PET Hepatic Lesion Detection Performance.

Bioengineering (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jul 12, 2025

High Speed Sub-GHz Spectrometer for Brillouin Scattering Analysis
13:31

High Speed Sub-GHz Spectrometer for Brillouin Scattering Analysis

Published on: December 22, 2015

15.1K

Performance evaluation of resolution and sensitivity of C-SPECT's variable slat-stack collimator.

Poopalasingam Sankar1, Dale J Stentz1, Lindsay C Johnson1

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Medical Physics
|October 31, 2023
PubMed
Summary

The C-SPECT system

Keywords:
SPECTcardiaccollimation

More Related Videos

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses
06:55

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Published on: June 6, 2017

7.6K
User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy
07:56

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

Published on: July 29, 2021

3.6K

Related Experiment Videos

Last Updated: Jul 12, 2025

High Speed Sub-GHz Spectrometer for Brillouin Scattering Analysis
13:31

High Speed Sub-GHz Spectrometer for Brillouin Scattering Analysis

Published on: December 22, 2015

15.1K
Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses
06:55

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Published on: June 6, 2017

7.6K
User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy
07:56

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

Published on: July 29, 2021

3.6K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Cardiovascular Imaging

Background:

  • Myocardial perfusion imaging commonly uses SPECT scanners, with limitations in dynamic imaging for general-purpose systems.
  • Dedicated systems like C-SPECT enable dynamic imaging due to rapid acquisition of complete projections.
  • C-SPECT features adaptive collimation for optimizing settings during fast dynamic imaging.

Purpose of the Study:

  • To evaluate the performance of axial direction adaptation in the C-SPECT system.
  • To characterize the system's ability to adjust collimator settings for dynamic myocardial perfusion imaging.

Main Methods:

  • Determined the resolution boost factor (high-sensitivity to high-resolution mode).
  • Calculated the sensitivity boost factor using similar methodology.
  • Compared experimental findings with theoretical predictions and simulation results.

Main Results:

  • The average resolution boost factor across 14 modules was 1.72.
  • The average sensitivity boost factor across 14 modules was 1.75.
  • Boost factors were approximately 10-15% below the ideal value of two.

Conclusions:

  • The C-SPECT system demonstrated reasonably successful adaptation between high-sensitivity and high-resolution modes.
  • Boost factors slightly below optimal suggest potential mechanical challenges, possibly related to collimator slat closure.
  • Findings indicate the adaptive collimation in C-SPECT shows promise for dynamic myocardial perfusion imaging.