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Accelerated Engineering of Optimized Functional Composite Hydrogels via High-Throughput Experimentation.

Yang Liu1,2, Junru Zhang1, Yujing Zhang3

  • 1Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.

ACS Applied Materials & Interfaces
|October 31, 2023
PubMed
Summary

A new high-throughput experimentation method enables rapid screening of hydrogel properties. This accelerates the engineering of advanced functional composite hydrogels for improved performance and processability.

Keywords:
Materials Genome Initiativehigh-throughput characterizationhigh-throughput synthesissensingsoft robotics

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biomaterials Engineering

Background:

  • The Materials Genome Initiative (MGI) aims to speed up advanced materials discovery.
  • Engineering functional materials often involves balancing processability and performance.
  • High-throughput experimentation (HTE) is crucial for accelerating materials development.

Purpose of the Study:

  • To develop and demonstrate an automated HTE method for soft materials.
  • To enable rapid screening of hydrogel composition-property relationships.
  • To optimize functional composite hydrogels for processability and performance.

Main Methods:

  • Automated formulation, synthesis, and multiproperty characterization of soft materials in well plate formats.
  • High-throughput screening of hydrogel composition-property relations.
  • Application to alginate/poly(N-isopropylacrylamide) (PNIPAM) and poly(ethylene glycol) dimethacrylate (PEGDMA)/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) hydrogel systems.

Main Results:

  • Demonstrated feasibility and utility of the HTE method for functional composite hydrogels.
  • Successfully identified formulations of conductive PEGDMA/PEDOT:PSS hydrogels.
  • Optimized hydrogel properties for both performance and processability in 3D printing.

Conclusions:

  • The developed HTE method accelerates the engineering of soft functional materials.
  • Automated dispensing, mixing, and sensing advance experimental capabilities for materials development.
  • This approach facilitates the creation of advanced composite hydrogels with tailored properties.