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Updated: Jul 12, 2025

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
[Neonatal ophthalmia caused by Herpes Simplex Virus type I]
María Pía Buzzetti1, Vanina Silva1, Álvaro Dendi1
1Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Abstract:
There are different etiologies of neonatal ophthalmia such as viral ones. Among them, the Herpes simplex virus, both type I and II, is particularly relevant due to its potential severity. It is a rare, in frequent entity, but with a high rate of morbidity and mortality without appropriate diagnosis and management.
Objective:
To describe a case of neonatal ophthalmia caused by Herpes Virus type I, its clinical characteristics, and correct diagnosis.
Clinical Case:
8-days old newborn, with no notable history, presenting edema and erythema of eyelids, accompanied by bilateral ocular discharge. Her pes Virus type I infection was diagnosed by PCR, without evidence of disseminated disease or central nervous system involvement. He received full treatment with intravenous Acyclovir with complete clinical improvement.
Conclusions:
Herpes Simplex Virus should always be considered as a diffe rential diagnosis in all neonatal ophthalmia. Early and timely diagnosis and treatment are of vital importance.
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