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Published on: March 1, 2019
Variation over Time in Child and Neighborhood Characteristics Associated with COVID-19
Sean Lang1,2, Lori Silveira1, Christiana Smith1,2
1Department of Pediatrics, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA.
Insights
COVID-19 disproportionately affected children in immigrant families early in the pandemic. Public health initiatives must address these disparities for vulnerable communities.
Area of Science:
- Pediatric infectious diseases
- Public health
- Epidemiology
Background:
- The COVID-19 pandemic highlighted existing health disparities.
- Understanding pediatric COVID-19 (SARS-CoV-2) infection drivers is crucial for targeted interventions.
Purpose of the Study:
- To investigate associations between child and neighborhood characteristics and pediatric COVID-19 infection incidence.
- To identify disparities in COVID-19 (SARS-CoV-2) risk among children.
Main Methods:
- Utilized electronic health records for 7498 pediatric COVID-19 (SARS-CoV-2) cases and census tract data.
- Employed multinomial logistic and negative binomial regression to analyze associations over three pandemic periods.
Main Results:
- Spanish preferred language and non-English preferred language were associated with higher COVID-19 (SARS-CoV-2) positivity, especially early in the pandemic.
- Increasing percentage of internationally born residents in a census tract correlated with higher COVID-19 (SARS-CoV-2) positivity rates throughout the study period.
Conclusions:
- Identified significant COVID-19 (SARS-CoV-2) disparities among children in immigrant families and communities.
- Emphasized the need for targeted public health investments to address these disparities.
Introduction:
To examine the associations between child and neighborhood characteristics and incidence of COVID-19 infection during the first 19 months of the pandemic.
Study Design:
We utilized individual electronic health record data and corresponding census tract characteristics for pediatric SARS-CoV-2 cases (age <18 years) from March 23, 2020 to September 30, 2021 with molecular tests resulted at a children's health system in Colorado. We compared associations between individual SARS-CoV-2 cases and census tract SARS-CoV-2 positivity rates over three time periods (TP1: March-September 2020; TP2: October 2020-March 2021; TP3: April-September 2021) using multinomial logistic regression for individual associations and negative binomial regression for census tract associations.
Results:
We included 7498 pediatric SARS-CoV-2 cases and data from 711 corresponding census tracts. Spanish preferred health care language was associated with SARS-CoV-2 positivity for TP1 (odds ratio [OR] 4.9, 95% confidence interval [CI] 3.7-6.5) and TP2 (OR 2.01, 95% CI 1.6-2.6) compared with TP3. Other non-English preferred health care language was associated with SARS-CoV-2 positivity in TP1 (OR 2.4, 95% CI 1.4-4.2). Increasing percentage internationally born in a census tract was associated with SARS-CoV-2 positivity for TP1 (multivariable incident rate ratio [IRR]=1.040, p<0.0001), TP2 (multivariable IRR=1.028, p<0.0001), and in all TP combined (multivariable IRR=1.024, p<0.0001).
Discussion:
Our study is notable for the identification of COVID-19 disparities among children in immigrant families and communities, particularly early in the pandemic. Addressing disparities for immigrant communities requires targeted investments in public health infrastructure.
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