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OBESITY AND GUT-BRAIN AXIS.

Dr Micic1, S Polovina2,3, Du Micic4

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The gut microbiome influences obesity by affecting the brain-gut axis. Understanding this connection may lead to new obesity treatments targeting gut bacteria.

Keywords:
enteroendocrine cellsgut microbiotagut-brain axisobesityvagus nerve

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Area of Science:

  • Microbiology
  • Neuroscience
  • Endocrinology

Background:

  • The global obesity epidemic is complex and multifactorial.
  • The brain-gut-microbiome axis is a key area of research for understanding food intake regulation.
  • Gut microbiota is increasingly recognized as an endocrine organ influencing metabolism and immunity.

Purpose of the Study:

  • To review current knowledge on the gut microbiota's role in obesity.
  • To explore the relationship between gut microbiota, the brain, and the gut-brain axis.
  • To discuss potential therapeutic strategies for obesity targeting the gut microbiota.

Main Methods:

  • Literature review of current research on gut microbiota and obesity.
  • Analysis of the interplay between gut microbiota, neuroendocrine, and immune systems.
  • Examination of bacterial metabolites and their impact on host physiology.

Main Results:

  • The gut microbiota significantly impacts energy homeostasis and host immunity.
  • Bidirectional signaling within the brain-gut-microbiome axis is crucial for controlling food intake.
  • Gut microbiota dysbiosis is implicated in the development of obesity and related metabolic diseases.

Conclusions:

  • The gut microbiota is a critical factor in obesity development.
  • Targeting the gut microbiota presents a promising avenue for novel obesity treatments.
  • Further research into the gut-brain-microbiome axis is essential for advancing obesity management.