Current Strategy of Monoclonal Antibody: Development, Cloning, Formulation and Drug Delivery

Area of Science:

• Biotechnology
• Immunology
• Pharmacology

Background:

• Monoclonal antibodies (mAbs) are crucial for understanding disease complexity and developing targeted therapies.
• Therapeutic mAbs have shown success in treating cancer, autoimmune, cardiovascular, and metabolic diseases.
• Effective delivery of mAbs in biological systems remains a significant challenge due to their properties.

Approach:

• This review examines the development of monoclonal antibodies (mAbs), including cloning methods for production.
• It focuses on various drug delivery technologies and formulation production for therapeutic mAbs.
• The review also covers the applications of mAbs in treating multiple diseases.

Key Points:

• Monoclonal antibodies enable targeted molecular identification and treatment, improving patient outcomes.
• Challenges in mAb drug delivery include large size, low stability, and achieving desired cellular action.
• Advanced cloning and formulation technologies are essential for enhancing mAb therapeutic potential.

Conclusions:

• Monoclonal antibodies represent a significant advancement in targeted therapeutics across various diseases.
• Overcoming drug delivery challenges is key to maximizing the clinical benefits of mAbs.
• Further research into mAb production and delivery systems will expand their therapeutic applications.