Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Inflammation01:38

Inflammation

53.7K
Overview
53.7K
Inflammatory Response01:28

Inflammatory Response

2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

507
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
507
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controllable protein assembly: from design strategies to functional applications.

Chemical communications (Cambridge, England)·2026
Same author

Development and preliminary evaluation of multiplex PCR assays for the detection of bacterial respiratory pathogens in bovine and ovine.

Veterinary and animal science·2026
Same author

Phospholipase Cβ regulates midgut homeostasis and defends against Bacillus thuringiensis in Spodoptera exigua.

Pesticide biochemistry and physiology·2026
Same author

A deep learning-assisted turn-on fluorescent probe for L-BPA detection with mechanistic insight.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Comparative Hepatic Transcriptomic Analysis Reveals Metabolic Regulatory Differences Between Qilian and Oula Sheep.

Veterinary sciences·2026
Same author

A comparative study of gut microbiota and metabolites in Tibetan sheep during cold and warm seasons.

Frontiers in veterinary science·2026

Related Experiment Video

Updated: Jul 12, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.3K

MST1/2 in inflammation and immunity.

Tongfen Li1, Yiqiong Wen1, Qiongfen Lu1

  • 1Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Cell Adhesion & Migration
|November 1, 2023
PubMed
Summary

Sterile 20-like kinase 1/2 (MST1/2) plays a key role in inflammation and immunity. MST1/2 can worsen inflammatory injury but also helps balance immune responses to prevent disease.

Keywords:
Immunityinflammationpathwaysthe mammalian Sterile 20-like 1the mammalian Sterile 20-like 2

More Related Videos

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

Related Experiment Videos

Last Updated: Jul 12, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.3K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Mammalian Sterile 20-like kinase 1/2 (MST1/2) is a serine/threonine protein kinase.
  • MST1/2 is integral to the regulation of inflammatory and immune responses.

Purpose of the Study:

  • To review the multifaceted roles of MST1/2 in modulating inflammation and immunity.
  • To elucidate the molecular pathways through which MST1/2 influences inflammatory injury and immune homeostasis.

Main Methods:

  • Literature review of studies investigating MST1/2 function.
  • Analysis of signaling pathways involving MST1/2, including JNK, NF-κB, and STAT.
  • Examination of regulatory factors like TNF-α, MIEF1, and LPS.

Main Results:

  • MST1/2 generally exacerbates inflammatory injury via pathways like MST1-JNK and MST1-NF-κB.
  • MST1/2 regulates immune balance through pathways such as MST1/2-Rac and MST1-STAT.
  • Key regulatory factors include TNF-α, MIEF1, LPS, and LFA-1.

Conclusions:

  • MST1/2 significantly impacts both the progression of inflammation and the regulation of immunity.
  • Understanding MST1/2 pathways is crucial for addressing inflammatory and autoimmune diseases.