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Updated: Jul 12, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Core-genome multilocus sequence typing and core-SNP analysis of Clostridium neonatale strains isolated in different
Victoria Mesa1, Johanne Delannoy1, Laurent Ferraris1
1Université Paris Cité, INSERM, UMR-S 1139 (3PHM), Faculté de Pharmacie de Paris , Paris, France.
Importance:
Clostridium neonatale has been isolated from the fecal samples of asymptomatic neonates and cases of necrotizing enterocolitis (NEC). Taking advantage of a large collection of independent strains isolated from different spatio-temporal settings, we developed and established a cgMLST scheme for the molecular typing of C. neonatale. Both the cgMLST and cgSNP methods demonstrate comparable discrimination power. Results indicate geographic- and temporal- independent clustering of C. neonatale NEC-associated strains. No specific cgMLST clade of C. neonatale was genetically associated with NEC.
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