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Updated: Jul 12, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[Estimating renal function in older patients : which is the best formula?]
Francesco Cilla1,2, Ilaria Sabione1, Menno Pruijm3
1Service de gériatrie aiguë et réadaptation gériatrique, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Abstract:
An accurate assessment of renal function is crucial for the diagnosis and follow up of kidney diseases. However, there is currently no clear consensus on the optimal method on how to measure renal function in older individuals (>65 years of age). The Cockcroft-Gault formula, the MDRD equation, and the CKD-EPI equation are among the most used equations. However, they have several limitations when applied to the older population. Other formulas specifically developed for the older, such as the Berlin Initiative Study (BIS) and the Full Age Spectrum (FAS) equation, demonstrated conflicting results and require more external validation. This article provides an overview of the currently available methods to assess renal function in the older persons and summarizes their shortcomings.
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