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Updated: Jul 12, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Enamine/Iminium-based Dual Organocatalytic Systems for Asymmetric Catalysis and Synthesis
Diksha Gambhir1, Sanjay Singh1, Ravi P Singh1
1Prof. Ravi P. Singh, Department of Chemistry, Institute of Technology Delhi, Hauz Khas, New Delhi, 110-016, India.
Abstract:
The rational combination of two catalysts to expedite the construction of chiral complex biologically and pharmacologically relevant chiral compounds has widely gained momentum over the past decade. In particular, enamine or iminium catalysis ensuing from the activation of aldehyde or ketone by chiral amine catalysts in conjugation with other organocatalytic cycles has facilitated several asymmetric transformations to yield the enantioenriched products. Regardless of the considerable discussion on the various dual catalytic approaches, literature lacks a comprehensive review focusing on the enamine and iminium-based dual organocatalytic systems. Thus, this review article has discussed the noteworthy achievements in the field of asymmetric catalysis and synthesis catalyzed by the enamine and iminium-based dual organocatalytic systems.
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